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FIG 12

SLFN5 expression is reduced in a large independent cohort of RCC patient samples and correlates with prognosis. (A) The RNA-seq data set from 470 RCC samples and 68 controls was downloaded from the TCGA Data Portal. Differential expression analysis was performed using Student's test. The resultant values were adjusted for false discovery rate (FDR) by using Benjamini and Hochberg's approach, and only adjusted values of <0.05 were considered statistically significant. The FDR value of the gene is 4.09E−06. (B to D) The Kaplan-Meier curves of high- and low-expression groups of candidate genes using RNA-seq data from 470 RCC samples. For each gene, the RCC samples were classified into high- or low-expression groups according to whether the expression of the candidate gene was greater than the median expression of the candidate gene. The values from log rank tests comparing the two Kaplan-Meier curves are shown in each figure. (B) Higher expression of SLFN5 leads to a better overall survival ( value = 0.0039). (C) Significant correlation between high MMP-13 expression and adverse overall survival ( value = 0.0098). (D) No significant correlation observed between MMP-1 and survival ( value = 0.136).

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Although the precise biochemical functions and mechanisms of action of members of the Schlafen family of proteins remain to be established, there has been emerging evidence implicating human SLFNs in the control of various cellular functions and in the pathophysiology of some diseases. Human SLFN11 has been shown to inhibit viral protein synthesis in HIV-infected cells ( 32 ) and to sensitize malignant cells to DNA-damaging agents and other chemotherapeutic cells ( Masago Slingback Sandals fmAA8hyqh
). Human SLFN5 has been implicated in the control of anchorage-independent growth of malignant melanoma cells ( 18 ), while human SLFN12 has been implicated in the control of differentiation of prostate epithelial cells ( Vince Camuto Chakeetan Suede Colorblock Strappy Dress Sandals jUMdBZkCPv

In the present study, we provide evidence implicating SLFN5 in RCC progression and invasiveness and, for the first time, identify a specific mechanism by which this occurs. Our studies establish that SLFN5 knockdown in renal cell carcinoma cells results in a distinct cellular phenotype characterized by a dramatic loss of stress fibers, a decrease in cell size, and enhanced cell motility. Using RNA-seq analysis, we identified groups of genes involved in cell morphology, as well as cellular assembly and organization, whose expression is increased upon SLFN5 knockdown in kidney cancer cells. Among these genes were MMP genes, whose protein products are involved in remodeling of the extracellular matrix (ECM) and play a role in RCC invasion ( 33 , Naturalizer Juniper LPHyGC
). Significantly, RNA interference (RNAi)-mediated targeting of MMP-1 and MMP-13 reverses the SLFN5 knockdown-induced invasion of RCC cells.

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Actor Shikha Talsania talks about playing a young mom onscreen, working with Kareena Kapoor Khan and the much talked about masturbation scene in Veere Di Wedding.

Monika Rawal Kukreja
Actor Shikha Talsania is the daughter of character actor Tiku Talsania, who is known for doing comic roles.

Actor Shikha Talsania, who got rave reviews for her performance in the recently released film, Veere Di Wedding, says that she always knew that this film is for her. Having played a young mother who is married to a white man, Shikha feels happy to have portrayed a character that defies the set societal norms. In a candid chat, Shikha talks about playing a young mom onscreen, working with Kareena Kapoor Khan and the much talked about masturbation scene in the film.

It’s been almost a month since the film released and it is still being talked about. How does it feel?

I’ve been with this film for such a long time and finally, to see the product out there, getting so much love… there’s overwhelming joy and excitement. I found the script ground breaking and I knew it would connect with people because it’s about real women with story set in the reality of today.

#bts What do you do when your Veere is getting hitched? Take a selfie ofcourse!!! #veere4life #veerdiwedding @vdwthefilm

A post shared by Shikha Talsania (@shikhatalsania) on

Swara Bhasker’s masturbation scene did not go down well with some people. Your views?

Honestly, I know how parents are reacting to it, as if they’ve never done it or been through that age (laughs) . VDW is a slice of life film and this masturbation scene was also a part of that. I understand it has to be done in the privacy of your bedroom and she [Swara’s character] was masturbating in the privacy of her bedroom. So, why this fuss! This slice of life film dwells into different aspects to women and what’s happening in their lives, so people will react to it in different ways. Those who appreciate it, it’s great. And those who found inspiration from it to talk further, it’s even better. If people are upset about it, that’s their problem, everyone has the right to give an opinion. When I read about the scene, I felt it was absolutely fantastic and quirky.

Some couples worry that their relationship must be unsatisfying if either one of them masturbates; this, too, is a myth.

Most men and women continue to masturbate either alone or together when they are in a relationship or married, and many find it an enjoyable part of their relationship.

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found that women who masturbated had happier marriages compared to those who did not masturbate.

Masturbation is harmless. Some people may experience chafing or tender skin if they are too rough, but this will usually heal in a few days.

If men frequently masturbate within a short space of time, they may experience a slight swelling of the penis called an edema . This swelling usually disappears within a couple of days.

Other potential side effects include:

Some people who worry that masturbation conflicts with their religious, spiritual, or cultural beliefs may experience feelings of guilt. However, masturbation is not immoral or wrong, and self-pleasure is not shameful.

Discussing feelings of guilt with a friend, healthcare professional, or therapist that specializes in sexual health might help a person to move past feelings of guilt or shame that they connect with masturbation.

If men have an aggressive masturbation method that involves too tight a grip on their penis, they can experience decreased sensation. A man can resolve this over time with a change of technique.

Enhanced stimulation, such as using a vibrator, may increase arousal and overall sexual function in both and women .

Women who use a vibrator have reported improved sexual function and lubrication, while men experienced an improvement in erectile function.

The jury is out as to whether masturbation increases or decreases the risk of prostate cancer . Researchers need to conduct more studies before they can reach a conclusion.

A 2003 study demonstrated that men who ejaculated more than five times each week during their 20s were one third less likely to develop aggressive prostate cancer than those who ejaculated less often.

Researchers speculate that the reduced risk was because frequent ejaculation may prevent the build-up of cancer-causing agents in the prostate gland.

A similar link between frequent ejaculation and a lower risk of prostate cancer was discovered in a Steve Madden ALINA Slingback Flat Sandal OznJuj
. Researchers found that men who ejaculated 21 times per month or more had a reduced risk of developing prostate cancer.

In contrast, a 2008 study found that frequent sexual activity during a man's 20s and 30s increased his risk of prostate cancer, especially if he masturbated regularly.

In rare cases, some individuals may masturbate more than they desire, which may:

Someone who thinks they might be adversely impacted by their masturbation practice should speak with a healthcare professional.

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